What could cause blisters on the palm of your hand?

At least twice per year (about 6 month intervals) my son gets blisters on the palm of his hand which burst and leave a sore. I have taken him to the doctor, done blood tests and still they cant find what is wrong. Is there the a name for this condition?

The Hand Foot and mouth virus gives you blisters on your hands, feet and you guessed it, in your mouth.
Does he have mouth ulcers at the same time?
Kids often get it from playing in sand pits.
It is highly contagious and can be quite uncomfortable, but goes on its own

Right Hand Palm Rule

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